6BA2
Crystal structure of MYST acetyltransferase domain in complex with inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 801 |
| Chain | Residue |
| A | ASP520 |
| A | HOH942 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | CYS540 |
| A | CYS543 |
| A | HIS556 |
| A | CYS560 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | ARG655 |
| A | LEU686 |
| A | NA807 |
| A | HOH992 |
| A | TYR549 |
| A | GLU550 |
| A | LYS551 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | LYS573 |
| A | ILE576 |
| A | GLN731 |
| A | HIS743 |
| A | ILE766 |
| A | HOH918 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 806 |
| Chain | Residue |
| A | ALY604 |
| A | THR605 |
| A | LEU606 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 807 |
| Chain | Residue |
| A | LYS551 |
| A | ASP685 |
| A | LEU686 |
| A | GOL803 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 808 |
| Chain | Residue |
| A | CYS543 |
| A | CYS560 |
| A | HOH982 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residues GOL A 805 and 7KM A 809 |
| Chain | Residue |
| A | PHE600 |
| A | LEU601 |
| A | ILE649 |
| A | GLN654 |
| A | ARG655 |
| A | ARG656 |
| A | GLY657 |
| A | TYR658 |
| A | GLY659 |
| A | ARG660 |
| A | SER684 |
| A | LEU686 |
| A | SER690 |
| A | SER693 |
| A | HOH956 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126 |
| Chain | Residue | Details |
| A | LEU537-TRP562 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:21217699, ECO:0000305|PubMed:27768893, ECO:0000305|PubMed:33657400 |
| Chain | Residue | Details |
| A | GLU680 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:27382063, ECO:0000269|PubMed:29321206, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2PQ8, ECO:0007744|PDB:2Y0M, ECO:0007744|PDB:3QAH, ECO:0007744|PDB:3TOA, ECO:0007744|PDB:3TOB, ECO:0007744|PDB:4DNC, ECO:0007744|PDB:5J8C, ECO:0007744|PDB:5J8F, ECO:0007744|PDB:5WCI |
| Chain | Residue | Details |
| A | CYS540 | |
| A | CYS543 | |
| A | HIS556 | |
| A | CYS560 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29321206, ECO:0007744|PDB:5WCI |
| Chain | Residue | Details |
| A | ILE647 | |
| A | ILE649 | |
| A | ARG655 | |
| A | GLY659 | |
| A | ARG660 | |
| A | SER684 | |
| A | SER693 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2Y0M |
| Chain | Residue | Details |
| A | ARG656 | |
| A | GLY657 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0007744|PDB:2Y0M |
| Chain | Residue | Details |
| A | TYR738 | |
| A | LYS762 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:27382063, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV |
| Chain | Residue | Details |
| A | ALY604 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER678 |
