6B97
Crystal structure of PDE2 in complex with complex 9
Summary for 6B97
Entry DOI | 10.2210/pdb6b97/pdb |
Descriptor | cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase 2, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408 |
Total number of polymer chains | 2 |
Total formula weight | 88404.65 |
Authors | |
Primary citation | Forster, A.B.,Abeywickrema, P.,Bunda, J.,Cox, C.D.,Cabalu, T.D.,Egbertson, M.,Fay, J.,Getty, K.,Hall, D.,Kornienko, M.,Lu, J.,Parthasarathy, G.,Reid, J.,Sharma, S.,Shipe, W.D.,Smith, S.M.,Soisson, S.,Stachel, S.J.,Su, H.P.,Wang, D.,Berger, R. The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design. Bioorg. Med. Chem. Lett., 27:5167-5171, 2017 Cited by PubMed: 29113762DOI: 10.1016/j.bmcl.2017.10.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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