6B97
Crystal structure of PDE2 in complex with complex 9
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 373 | 43694.8 | 2 | UniProt (O00408) Pfam (PF00233) In PDB | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | 6-chloro-1-methyl-N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 355.7 | 2 | Chemie (CZY) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
6 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence modifications
A, B: 578 - 919 (UniProt: O00408)
PDB | External Database | Details |
---|---|---|
Met 547 | - | initiating methionine |
His 548 | - | expression tag |
His 549 | - | expression tag |
His 550 | - | expression tag |
His 551 | - | expression tag |
His 552 | - | expression tag |
His 553 | - | expression tag |
Glu 554 | - | expression tag |
Asn 555 | - | expression tag |
Leu 556 | - | expression tag |
Tyr 557 | - | expression tag |
Phe 558 | - | expression tag |
Gln 559 | - | expression tag |
Gly 560 | - | expression tag |
Glu 561 | - | expression tag |
Leu 562 | - | expression tag |
Ser 563 | - | expression tag |
Thr 564 | - | expression tag |
Ser 565 | - | expression tag |
Leu 566 | - | expression tag |
Tyr 567 | - | expression tag |
Lys 568 | - | expression tag |
Lys 569 | - | expression tag |
Ala 570 | - | expression tag |
Gly 571 | - | expression tag |
Phe 572 | - | expression tag |
Asp 573 | - | expression tag |
Asp 574 | - | expression tag |
Asp 575 | - | expression tag |
Asp 576 | - | expression tag |
Lys 577 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 87389.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1015.1 | |
All* | Total formula weight | 88404.6 |