6B97

Crystal structure of PDE2 in complex with complex 9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS660
A	HIS696
A	ASP697
A	ASP808
A	HOH1106
A	HOH1199

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1002

Chain	Residue
A	HOH1139
A	HOH1160
A	HOH1209
A	ASP697
A	HOH1106
A	HOH1120

---

site_id	AC3
Number of Residues	10
Details	binding site for residue CZY A 1003

Chain	Residue
A	THR768
A	LEU770
A	THR805
A	ASP808
A	GLN812
A	TYR827
A	PHE830
A	PHE862
A	HOH1133
A	HOH1227

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 1004

Chain	Residue
A	PHE572
A	GLN733
A	HOH1113
A	HOH1194
A	HOH1196

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 1005

Chain	Residue
A	ILE735
A	ASN739
A	TYR754

---

site_id	AC6
Number of Residues	6
Details	binding site for residue ZN B 1001

Chain	Residue
B	HIS660
B	HIS696
B	ASP697
B	ASP808
B	HOH1105
B	HOH1181

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG B 1002

Chain	Residue
B	ASP697
B	HOH1105
B	HOH1134
B	HOH1138
B	HOH1170
B	HOH1242

---

site_id	AC8
Number of Residues	14
Details	binding site for residue CZY B 1003

Chain	Residue
B	TYR655
B	THR768
B	LEU770
B	THR805
B	ASP808
B	LEU809
B	GLN812
B	ILE826
B	TYR827
B	PHE830
B	GLN859
B	PHE862
B	HOH1164
B	HOH1211

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---