6B8J
Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor
Summary for 6B8J
Entry DOI | 10.2210/pdb6b8j/pdb |
Descriptor | Glycogen synthase kinase-3 beta, VAL-SEP-ARG-ARG, GLYCEROL, ... (5 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P49841 |
Total number of polymer chains | 2 |
Total formula weight | 48037.22 |
Authors | |
Primary citation | Wagman, A.S.,Boyce, R.S.,Brown, S.P.,Fang, E.,Goff, D.,Jansen, J.M.,Le, V.P.,Levine, B.H.,Ng, S.C.,Ni, Z.J.,Nuss, J.M.,Pfister, K.B.,Ramurthy, S.,Renhowe, P.A.,Ring, D.B.,Shu, W.,Subramanian, S.,Zhou, X.A.,Shafer, C.M.,Harrison, S.D.,Johnson, K.W.,Bussiere, D.E. Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. J. Med. Chem., 60:8482-8514, 2017 Cited by PubMed: 29016121DOI: 10.1021/acs.jmedchem.7b00922 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.595 Å) |
Structure validation
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