6B6G

Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction

Summary for 6B6G

Entry DOI	10.2210/pdb6b6g/pdb
Descriptor	4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid, ... (6 entities in total)
Functional Keywords	inactivator, gaba aminotransferase, plp, transferase
Biological source	Sus scrofa (Pig)
Total number of polymer chains	4
Total formula weight	211620.30
Authors	Mascarenhas, R.,Juncosa, J.I.,Takaya, K.,Le, L.V.,Moschitto, M.J.,Silverman, R.B.,Liu, D. (deposition date: 2017-10-02, release date: 2018-02-14, Last modification date: 2024-03-13)
Primary citation	Juncosa, J.I.,Takaya, K.,Le, H.V.,Moschitto, M.J.,Weerawarna, P.M.,Mascarenhas, R.,Liu, D.,Dewey, S.L.,Silverman, R.B. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. J. Am. Chem. Soc., 140:2151-2164, 2018 Cited by PubMed: 29381352 DOI: 10.1021/jacs.7b10965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation