6B6G
Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 4-aminobutyrate aminotransferase, mitochondrial | polymer | 462 | 52311.8 | 4 | UniProt (P80147) Pfam (PF00202) | Sus scrofa (Pig) | (S)-3-amino-2-methylpropionate transaminase,GABA aminotransferase,GABA-AT,Gamma-amino-N-butyrate transaminase,GABA-T,L-AIBAT |
| 2 | E, K (A, C) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 3 | F, J, M, O (A, B, C, D) | (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid | non-polymer | 400.3 | 4 | Chemie (RMT) | |||
| 4 | G, H, N, P (A, C, D) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 5 | I, L (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 1336 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 11 - 472 (UniProt: P80147)
| PDB | External Database | Details |
|---|---|---|
| Glu 158 | Gln 186 | conflict |
| Ala 472 | Lys 500 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 209247.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2373.1 | |
| All* | Total formula weight | 211620.3 |
