6B5B

Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome

Summary for 6B5B

Entry DOI	10.2210/pdb6b5b/pdb
EMDB information	7055
Descriptor	Baculoviral IAP repeat-containing protein 1e, NLR family CARD domain-containing protein 4, Flagellin (3 entities in total)
Functional Keywords	innate immunity, molecular complex, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	452140.90
Authors	Tenthorey, J.L.,Haloupek, N.,Lopez-Blanco, J.R.,Grob, P.,Adamson, E.,Hartenian, E.,Lind, N.A.,Bourgeois, N.M.,Chacon, P.,Nogales, E.,Vance, R.E. (deposition date: 2017-09-29, release date: 2017-11-15, Last modification date: 2024-03-13)
Primary citation	Tenthorey, J.L.,Haloupek, N.,Lopez-Blanco, J.R.,Grob, P.,Adamson, E.,Hartenian, E.,Lind, N.A.,Bourgeois, N.M.,Chacon, P.,Nogales, E.,Vance, R.E. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science, 358:888-893, 2017 Cited by PubMed: 29146805 DOI: 10.1126/science.aao1140 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.2 Å)

Structure validation