6B3S

Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)

Summary for 6B3S

Entry DOI	10.2210/pdb6b3s/pdb
Descriptor	Epidermal growth factor receptor, Necitumumab Fab Heavy chain, Necitumumab Fab Light chain, ... (8 entities in total)
Functional Keywords	therapeutic antibody, cetuximab resistance, somatic mutation, colorectal cancer, transferase, transferase-immune system complex, transferase/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	287582.73
Authors	Ferguson, K.M.,Bagchi, A. (deposition date: 2017-09-23, release date: 2017-12-06, Last modification date: 2023-10-04)
Primary citation	Bagchi, A.,Haidar, J.N.,Eastman, S.W.,Vieth, M.,Topper, M.,Iacolina, M.D.,Walker, J.M.,Forest, A.,Shen, Y.,Novosiadly, R.D.,Ferguson, K.M. Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol. Cancer Ther., 17:521-531, 2018 Cited by PubMed: 29158469 DOI: 10.1158/1535-7163.MCT-17-0575 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation