6B0T

Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule

Summary for 6B0T

• Entry DOI: 10.2210/pdb6b0t/pdb
• Descriptor: Fascin, 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide (3 entities in total)
• Functional Keywords: metastaic cancers, small-molecule inhibitors, actin-bundling, domain rotation, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 326559.58

Authors

Dey, R.,Huang, X.Y. (deposition date: 2017-09-15, release date: 2018-04-18, Last modification date: 2023-10-04)

• Primary citation: Huang, J.,Dey, R.,Wang, Y.,Jakoncic, J.,Kurinov, I.,Huang, X.Y.; Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.; J. Mol. Biol., 430:1324-1335, 2018; PubMed: 29573988; DOI: 10.1016/j.jmb.2018.03.009

Experimental method

X-RAY DIFFRACTION (2.8 Å)