6B0T

Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule

6B0T の概要

• エントリーDOI: 10.2210/pdb6b0t/pdb
• 分子名称: Fascin, 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide (3 entities in total)
• 機能のキーワード: metastaic cancers, small-molecule inhibitors, actin-bundling, domain rotation, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 326559.58

構造登録者

Dey, R.,Huang, X.Y. (登録日: 2017-09-15, 公開日: 2018-04-18, 最終更新日: 2023-10-04)

• 主引用文献: Huang, J.,Dey, R.,Wang, Y.,Jakoncic, J.,Kurinov, I.,Huang, X.Y.; Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.; J. Mol. Biol., 430:1324-1335, 2018; PubMed: 29573988; DOI: 10.1016/j.jmb.2018.03.009

実験手法

X-RAY DIFFRACTION (2.8 Å)