6B0R
Zinc finger Domain of WT1(-KTS form) with M342R Mutation and 14+1mer Oligonucleotide with 3' Triplet TGG
Summary for 6B0R
Entry DOI | 10.2210/pdb6b0r/pdb |
Related | 6B0O 6B0P 6B0Q |
Descriptor | Wilms tumor protein, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*GP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*CP*GP*C)-3'), ... (6 entities in total) |
Functional Keywords | protein-dna complex wilms tumor suppressor protein zinc-fingers, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544 |
Total number of polymer chains | 6 |
Total formula weight | 48313.19 |
Authors | Horton, J.R.,Cheng, X. (deposition date: 2017-09-14, release date: 2018-01-03, Last modification date: 2024-03-13) |
Primary citation | Wang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res., 46:3864-3877, 2018 Cited by PubMed: 29294058DOI: 10.1093/nar/gkx1274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.818 Å) |
Structure validation
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