6B0R

Zinc finger Domain of WT1(-KTS form) with M342R Mutation and 14+1mer Oligonucleotide with 3' Triplet TGG

Summary for 6B0R

• Entry DOI: 10.2210/pdb6b0r/pdb
• Related: 6B0O 6B0P 6B0Q
• Descriptor: Wilms tumor protein, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*GP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*CP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: protein-dna complex wilms tumor suppressor protein zinc-fingers, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544
• Total number of polymer chains: 6
• Total formula weight: 48313.19

Authors

Horton, J.R.,Cheng, X. (deposition date: 2017-09-14, release date: 2018-01-03, Last modification date: 2024-03-13)

• Primary citation: Wang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.; Nucleic Acids Res., 46:3864-3877, 2018; PubMed: 29294058; DOI: 10.1093/nar/gkx1274

Experimental method

X-RAY DIFFRACTION (1.818 Å)