6B0E

Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260

Summary for 6B0E

• Entry DOI: 10.2210/pdb6b0e/pdb
• Related: 6AZZ 6B08 6B0A
• Descriptor: 1260 antibody, light chain, 1260 antibody, heavy chain, 25 kDa ookinete surface antigen (3 entities in total)
• Functional Keywords: transmission blocking vaccine, malaria, antibody, egf-like domain, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Lipid-anchor, GPI-anchor : P13829
• Total number of polymer chains: 3
• Total formula weight: 68652.22

Authors

Scally, S.W.,McLeod, B.,Bosch, A.,King, C.R.,Julien, J.P. (deposition date: 2017-09-14, release date: 2017-11-15, Last modification date: 2023-10-04)

• Primary citation: Scally, S.W.,McLeod, B.,Bosch, A.,Miura, K.,Liang, Q.,Carroll, S.,Reponen, S.,Nguyen, N.,Giladi, E.,Ramisch, S.,Yusibov, V.,Bradley, A.,Lemiale, F.,Schief, W.R.,Emerling, D.,Kellam, P.,King, C.R.,Julien, J.P.; Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.; Nat Commun, 8:1568-1568, 2017; PubMed: 29146922; DOI: 10.1038/s41467-017-01924-3

Experimental method

X-RAY DIFFRACTION (3.3 Å)