6AXG

Structure of RasGRP4 in complex with HRas

Summary for 6AXG

Entry DOI	10.2210/pdb6axg/pdb
Descriptor	RAS guanyl-releasing protein 4, GTPase HRas (2 entities in total)
Functional Keywords	signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q8TDF6 Cell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains	12
Total formula weight	395195.29
Authors	Kondo, Y.,Iwig, J.S.,Kuriyan, J. (deposition date: 2017-09-06, release date: 2017-10-11, Last modification date: 2023-10-04)
Primary citation	Vercoulen, Y.,Kondo, Y.,Iwig, J.S.,Janssen, A.,White, K.A.,Amini, M.,Barber, D.L.,Kuriyan, J.,Roose, J.P. A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife, 6:-, 2017 Cited by PubMed: 28952923 DOI: 10.7554/eLife.29002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.302 Å)

Structure validation