6AXG

Structure of RasGRP4 in complex with HRas

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0007264	biological_process	small GTPase-mediated signal transduction
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0007264	biological_process	small GTPase-mediated signal transduction
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0007264	biological_process	small GTPase-mediated signal transduction
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0007264	biological_process	small GTPase-mediated signal transduction
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0007264	biological_process	small GTPase-mediated signal transduction
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
K	0005085	molecular_function	guanyl-nucleotide exchange factor activity
K	0007264	biological_process	small GTPase-mediated signal transduction
L	0003924	molecular_function	GTPase activity
L	0005525	molecular_function	GTP binding
L	0007165	biological_process	signal transduction
L	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269|PubMed:16698776

Chain	Residue	Details
B	GLY13
D	SER145
F	GLY13
F	VAL29
F	ALA59
F	ASN116
F	SER145
H	GLY13
H	VAL29
H	ALA59
H	ASN116
B	VAL29
H	SER145
J	GLY13
J	VAL29
J	ALA59
J	ASN116
J	SER145
L	GLY13
L	VAL29
L	ALA59
L	ASN116
B	ALA59
L	SER145
B	ASN116
B	SER145
D	GLY13
D	VAL29
D	ALA59
D	ASN116

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12

Chain	Residue	Details
B	MET1
D	MET1
F	MET1
H	MET1
J	MET1
L	MET1

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
B	THR2
D	THR2
F	THR2
H	THR2
J	THR2
L	THR2

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
B	CYS118
D	CYS118
F	CYS118
H	CYS118
J	CYS118
L	CYS118

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
B	THR35
D	THR35
F	THR35
H	THR35
J	THR35
L	THR35

---