6AXG

Structure of RasGRP4 in complex with HRas

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0007264	biological_process	small GTPase-mediated signal transduction
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0007264	biological_process	small GTPase-mediated signal transduction
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0007264	biological_process	small GTPase-mediated signal transduction
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0007264	biological_process	small GTPase-mediated signal transduction
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0007264	biological_process	small GTPase-mediated signal transduction
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
K	0005085	molecular_function	guanyl-nucleotide exchange factor activity
K	0007264	biological_process	small GTPase-mediated signal transduction
L	0003924	molecular_function	GTPase activity
L	0005525	molecular_function	GTP binding
L	0007165	biological_process	signal transduction
L	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	24
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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