6AX4
Plk-1 polo-box domain in complex with histidine N(tau)-cyclized Macrocycle 5b.
Summary for 6AX4
Entry DOI | 10.2210/pdb6ax4/pdb |
Descriptor | Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE, ... (4 entities in total) |
Functional Keywords | macrocyclic phosphopeptide, mitotic kinase. polo-box domain, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28236.26 |
Authors | Grant, R.A.,Hymel, D.,Yaffe, M.B.,Burke, T.R. (deposition date: 2017-09-06, release date: 2018-09-12, Last modification date: 2023-11-15) |
Primary citation | Hymel, D.,Grant, R.A.,Tsuji, K.,Yaffe, M.B.,Burke Jr., T.R. Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg. Med. Chem. Lett., 28:3202-3205, 2018 Cited by PubMed: 30174151DOI: 10.1016/j.bmcl.2018.08.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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