6AX4

Plk-1 polo-box domain in complex with histidine N(tau)-cyclized Macrocycle 5b.

Summary for 6AX4

Entry DOI	10.2210/pdb6ax4/pdb
Descriptor	Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE, ... (4 entities in total)
Functional Keywords	macrocyclic phosphopeptide, mitotic kinase. polo-box domain, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28236.26
Authors	Grant, R.A.,Hymel, D.,Yaffe, M.B.,Burke, T.R. (deposition date: 2017-09-06, release date: 2018-09-12, Last modification date: 2023-11-15)
Primary citation	Hymel, D.,Grant, R.A.,Tsuji, K.,Yaffe, M.B.,Burke Jr., T.R. Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg. Med. Chem. Lett., 28:3202-3205, 2018 Cited by PubMed: 30174151 DOI: 10.1016/j.bmcl.2018.08.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation