6AX1
Structure of human monoacylglycerol lipase bound to a covalent inhibitor
Summary for 6AX1
Entry DOI | 10.2210/pdb6ax1/pdb |
Descriptor | Monoglyceride lipase, 1,1,1,3,3,3-hexafluoropropan-2-yl 3-(3-phenyl-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | monoacylglycerol lipase, covalent inhibitor, sbdd, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : Q99685 |
Total number of polymer chains | 2 |
Total formula weight | 77584.17 |
Authors | |
Primary citation | Butler, C.R.,Beck, E.M.,Harris, A.,Huang, Z.,McAllister, L.A.,Am Ende, C.W.,Fennell, K.,Foley, T.L.,Fonseca, K.,Hawrylik, S.J.,Johnson, D.S.,Knafels, J.D.,Mente, S.,Noell, G.S.,Pandit, J.,Phillips, T.B.,Piro, J.R.,Rogers, B.N.,Samad, T.A.,Wang, J.,Wan, S.,Brodney, M.A. Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. J. Med. Chem., 60:9860-9873, 2017 Cited by PubMed: 29148769DOI: 10.1021/acs.jmedchem.7b01531 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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