6AX1
Structure of human monoacylglycerol lipase bound to a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Monoglyceride lipase | polymer | 348 | 38258.7 | 2 | UniProt (Q99685) Pfam (PF12146) | Homo sapiens (Human) | MGL,HU-K5,Lysophospholipase homolog,Lysophospholipase-like,Monoacylglycerol lipase,MAGL |
| 2 | C, F (A, B) | 1,1,1,3,3,3-hexafluoropropan-2-yl 3-(3-phenyl-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate | non-polymer | 395.3 | 2 | Chemie (C0S) | |||
| 3 | D, E, G (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 409 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 303 (UniProt: Q99685)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | expression tag |
| Ala -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Arg -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Arg -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 304 | - | expression tag |
| Glu 305 | - | expression tag |
| Val 306 | - | expression tag |
| Asp 307 | - | expression tag |
| Leu 308 | - | expression tag |
| Gln 309 | - | expression tag |
| Gly 310 | - | expression tag |
| Asp 311 | - | expression tag |
| His 312 | - | expression tag |
| Gly 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Ser 315 | - | expression tag |
| Ala 316 | - | expression tag |
| Trp 317 | - | expression tag |
| Ser 318 | - | expression tag |
| His 319 | - | expression tag |
| Pro 320 | - | expression tag |
| Gln 321 | - | expression tag |
| Phe 322 | - | expression tag |
| Glu 323 | - | expression tag |
| Lys 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76517.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1066.8 | |
| All* | Total formula weight | 77584.2 |
