6AUY
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-Methyl-6-(3-(3-(methylamino)propyl)phenethyl)pyridin-2-amine
Summary for 6AUY
Entry DOI | 10.2210/pdb6auy/pdb |
Related | 6AUQ 6AUR 6AUS 6AUT 6AUU 6AUV 6AUW 6AUX 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6AV6 6AV7 |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 100285.07 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2017-09-01, release date: 2018-07-11, Last modification date: 2023-10-04) |
Primary citation | Do, H.T.,Wang, H.Y.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60:9360-9375, 2017 Cited by PubMed: 29091437DOI: 10.1021/acs.jmedchem.7b01356 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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