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6AUQ

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-Methyl-6-(3-(3-(methylamino)propyl)phenethyl)pyridin-2-amine

Summary for 6AUQ
Entry DOI10.2210/pdb6auq/pdb
Related6AUR 6AUS 6AUT 6AUU 6AUV 6AUW 6AUX 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6AV6 6AV7
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase inhibitor complex heme enzyme, oxidoreductase
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains2
Total formula weight100090.84
Authors
Li, H.,Poulos, T.L. (deposition date: 2017-09-01, release date: 2018-07-11, Last modification date: 2023-10-04)
Primary citationDo, H.T.,Wang, H.Y.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60:9360-9375, 2017
Cited by
PubMed: 29091437
DOI: 10.1021/acs.jmedchem.7b01356
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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