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6AUY

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-Methyl-6-(3-(3-(methylamino)propyl)phenethyl)pyridin-2-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BNitric oxide synthase, brainpolymer42148784.52UniProt (P29475)
Pfam (PF02898)
In PDB
Homo sapiens (Human)Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1,bNOS
2A, BPROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3A, B5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.22Chemie (H4B)
4AZINC IONnon-polymer65.41Chemie (ZN)
5A, B4-methyl-6-(2-{3-[3-(methylamino)propyl]phenyl}ethyl)pyridin-2-aminenon-polymer283.42Chemie (BYJ)
6A, BGLYCEROLnon-polymer92.14Chemie (GOL)
7waterwater18.0472Chemie (HOH)
Sequence modifications
A, B: 302 - 722 (UniProt: P29475)
PDBExternal DatabaseDetails
Ala 354Arg 354engineered mutation
Asp 357Gly 357engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight97569.0
Non-Polymers*Number of molecules11
Total formula weight2716.1
All*Total formula weight100285.1
*Water molecules are not included.

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PDB entries from 2024-07-17

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