6AUB

CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR CGI2815

Summary for 6AUB

Related6AUA
DescriptorTyrosine-protein kinase BTK, SULFATE ION, 4-tert-butyl-N-[2-methyl-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]benzamide, ... (4 entities in total)
Functional Keywordsbtk, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight31733.45
Authors
Davies, D.R.,Staker, B.L. (deposition date: 2017-08-31, release date: 2018-09-12)
Primary citation
Ortwine, D.
To Be Determined
TO BE PUBLISHED,
Experimental method
X-RAY DIFFRACTION (1.65 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1991000.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 6aub
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