6AU3

Crystal structure of SETDB1 Tudor domain with aryl triazole fragments

Summary for 6AU3

• Entry DOI: 10.2210/pdb6au3/pdb
• Descriptor: Histone-lysine N-methyltransferase SETDB1, N-{[2-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)phenyl]methyl}acetamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: setdb1 tudor, fragment hits, epigenetics, methyllysine reader, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q15047
• Total number of polymer chains: 1
• Total formula weight: 25578.37

Authors

MADER, P.,Mendoza-Sanchez, R.,IQBAL, A.,DONG, A.,DOBROVETSKY, E.,CORLESS, V.B.,LIEW, S.K.,TEMPEL, W.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.,HOLOWNIA, A.,VEDADI, M.,BROWN, P.J.,SANTHAKUMAR, V.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2017-08-30, release date: 2017-09-27, Last modification date: 2024-03-13)

• Primary citation: MADER, P.,Mendoza-Sanchez, R.,IQBAL, A.,DONG, A.,DOBROVETSKY, E.,CORLESS, V.B.,LIEW, S.K.,TEMPEL, W.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.,HOLOWNIA, A.,VEDADI, M.,BROWN, P.J.,SANTHAKUMAR, V.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC); Crystal structure of SETDB1 Tudor domain with aryl triazole fragments; to be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)