6ASC
Mre11 dimer in complex with Endonuclease inhibitor PFM04
Summary for 6ASC
Entry DOI | 10.2210/pdb6asc/pdb |
Descriptor | Nuclease SbcCD subunit D, MANGANESE (II) ION, (5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (5 entities in total) |
Functional Keywords | dna repair mre11 thermophilic nuclease dna double-strand break repair hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Thermotoga maritima |
Total number of polymer chains | 2 |
Total formula weight | 78019.06 |
Authors | Moiani, D.,Arvai, A.S.,Tainer, J.A. (deposition date: 2017-08-24, release date: 2018-03-07, Last modification date: 2024-03-13) |
Primary citation | Moiani, D.,Ronato, D.A.,Brosey, C.A.,Arvai, A.S.,Syed, A.,Masson, J.Y.,Petricci, E.,Tainer, J.A. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Meth. Enzymol., 601:205-241, 2018 Cited by PubMed: 29523233DOI: 10.1016/bs.mie.2017.11.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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