6AS7
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP
Summary for 6AS7
Entry DOI | 10.2210/pdb6as7/pdb |
Related | 4qcl |
Descriptor | DNA polymerase alpha catalytic subunit, DNA (5'-D(*GP*CP*CP*TP*GP*GP*AP*GP*CP*GP*C)-3'), DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ... (7 entities in total) |
Functional Keywords | b-family dna polymerase, dna replication, replication, replication-dna complex, replication/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 113570.22 |
Authors | Tahirov, T.H.,Baranovskiy, A.G.,Babayeva, N.D. (deposition date: 2017-08-23, release date: 2018-03-14, Last modification date: 2023-10-04) |
Primary citation | Baranovskiy, A.G.,Duong, V.N.,Babayeva, N.D.,Zhang, Y.,Pavlov, Y.I.,Anderson, K.S.,Tahirov, T.H. Activity and fidelity of human DNA polymerase alpha depend on primer structure. J. Biol. Chem., 293:6824-6843, 2018 Cited by PubMed: 29555682DOI: 10.1074/jbc.RA117.001074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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