6AS7
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase alpha catalytic subunit | polymer | 922 | 105583.8 | 1 | UniProt (P09884) Pfam (PF03104) Pfam (PF00136) | Homo sapiens (Human) | DNA polymerase alpha catalytic subunit p180 |
| 2 | B (B) | DNA (5'-D(*GP*CP*CP*TP*GP*GP*AP*GP*CP*GP*C)-3') | polymer | 11 | 3375.2 | 1 | unidentified | ||
| 3 | C (C) | DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3') | polymer | 13 | 3977.6 | 1 | unidentified | ||
| 4 | D (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) | |||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | G, H (B, C) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 7 | I (B) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 336 - 1257 (UniProt: P09884)
| PDB | External Database | Details |
|---|---|---|
| Ala 516 | Val 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112936.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 633.6 | |
| All* | Total formula weight | 113570.2 |
