6AS7

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	1902975	biological_process	mitotic DNA replication initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue DCP A 1301

Chain	Residue
A	ASP860
A	THR1003
A	ASP1004
A	MG1302
A	MG1303
B	DC11
C	DG110
C	DG111
A	PHE861
A	ASN862
A	SER863
A	LEU864
A	TYR865
A	LYS950
A	ASN954
A	TYR957

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 1302

Chain	Residue
A	ASP860
A	PHE861
A	ASP1004
A	DCP1301
A	MG1303

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 1303

Chain	Residue
A	ASP860
A	ASP1004
A	DCP1301
A	MG1302

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CO B 101

Chain	Residue
B	DG5

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CO C 401

Chain	Residue
C	DG119

---

Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI

Chain	Residue	Details
A	TYR1000-ILE1008

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P33609","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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