6ARK
Crystal Structure of compound 10 covalently bound to K-Ras G12C
Summary for 6ARK
Entry DOI | 10.2210/pdb6ark/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | dockovalent, covalent docking, k-ras g12c, covalent inhibitors, covalent fragments, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20395.74 |
Authors | Nnadi, C.I.,Jenkins, M.L.,Gentile, D.R.,Bateman, L.A.,Zaidman, D.,Balius, T.E.,Nomura, D.K.,Burke, J.E.,Shokat, K.M.,London, N. (deposition date: 2017-08-22, release date: 2018-01-31, Last modification date: 2023-10-04) |
Primary citation | Nnadi, C.I.,Jenkins, M.L.,Gentile, D.R.,Bateman, L.A.,Zaidman, D.,Balius, T.E.,Nomura, D.K.,Burke, J.E.,Shokat, K.M.,London, N. Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model, 58:464-471, 2018 Cited by PubMed: 29320178DOI: 10.1021/acs.jcim.7b00399 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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