6APD

Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425

6APD の概要

• エントリーDOI: 10.2210/pdb6apd/pdb
• 分子名称: Fusion glycoprotein F0,Envelope glycoprotein, AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, ... (5 entities in total)
• 機能のキーワード: viral glycoprotein, immunoglobulin, infant, complex, immune system
• 由来する生物種: Respiratory syncytial virus; 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 474123.09

構造登録者

Wrapp, D.,McLellan, J.S. (登録日: 2017-08-17, 公開日: 2018-03-21, 最終更新日: 2020-01-01)

• 主引用文献: Goodwin, E.,Gilman, M.S.A.,Wrapp, D.,Chen, M.,Ngwuta, J.O.,Moin, S.M.,Bai, P.,Sivasubramanian, A.,Connor, R.I.,Wright, P.F.,Graham, B.S.,McLellan, J.S.,Walker, L.M.; Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.; Immunity, 48:339-349.e5, 2018; PubMed: 29396163; DOI: 10.1016/j.immuni.2018.01.005

実験手法

X-RAY DIFFRACTION (4.1 Å)