6AOD

FXIa antibody complex

Summary for 6AOD

• Entry DOI: 10.2210/pdb6aod/pdb
• Descriptor: FXIa Antibody FAB Light Chain, FXIa Antibody FAB Heavy Chain, Coagulation factor XI, ... (8 entities in total)
• Functional Keywords: fxia antibody fab, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• Biological source: Homo sapiens; More
• Cellular location: Secreted: P03951
• Total number of polymer chains: 3
• Total formula weight: 77676.81

Authors

Lolicato, M.,Minor, D.L. (deposition date: 2017-08-15, release date: 2018-03-14, Last modification date: 2023-10-04)

• Primary citation: Ely, L.K.,Lolicato, M.,David, T.,Lowe, K.,Kim, Y.C.,Samuel, D.,Bessette, P.,Garcia, J.L.,Mikita, T.,Minor, D.L.,Coughlin, S.R.; Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.; Structure, 26:187-198.e4, 2018; PubMed: 29336885; DOI: 10.1016/j.str.2017.12.010

Experimental method

X-RAY DIFFRACTION (1.8 Å)