6AMB
Crystal Structure of the Afadin RA1 domain in complex with HRAS
Summary for 6AMB
Entry DOI | 10.2210/pdb6amb/pdb |
Descriptor | GTPase HRas, Afadin, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | gtpase, adhesion, ra domain, rbd domain, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 Cell junction, adherens junction: Q9QZQ1 |
Total number of polymer chains | 2 |
Total formula weight | 31462.41 |
Authors | Smith, M.J.,Ishiyama, N.,Ikura, M. (deposition date: 2017-08-09, release date: 2017-11-01, Last modification date: 2023-10-04) |
Primary citation | Smith, M.J.,Ottoni, E.,Ishiyama, N.,Goudreault, M.,Haman, A.,Meyer, C.,Tucholska, M.,Gasmi-Seabrook, G.,Menezes, S.,Laister, R.C.,Minden, M.D.,Marschalek, R.,Gingras, A.C.,Hoang, T.,Ikura, M. Evolution of AF6-RAS association and its implications in mixed-lineage leukemia. Nat Commun, 8:1099-1099, 2017 Cited by PubMed: 29062045DOI: 10.1038/s41467-017-01326-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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