6ALC

CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)

Summary for 6ALC

• Entry DOI: 10.2210/pdb6alc/pdb
• Related: 6ALB
• Descriptor: CREB-binding protein, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: crebbp, bromodomain, small molecule inhibitor, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 27565.55

Authors

Murray, J.M. (deposition date: 2017-08-07, release date: 2018-08-08, Last modification date: 2023-10-04)

• Primary citation: Lai, K.W.,Romero, F.A.,Tsui, V.,Beresini, M.H.,de Leon Boenig, G.,Bronner, S.M.,Chen, K.,Chen, Z.,Choo, E.F.,Crawford, T.D.,Cyr, P.,Kaufman, S.,Li, Y.,Liao, J.,Liu, W.,Ly, J.,Murray, J.,Shen, W.,Wai, J.,Wang, F.,Zhu, C.,Zhu, X.,Magnuson, S.; Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.; Bioorg. Med. Chem. Lett., 28:15-23, 2018; PubMed: 29169673; DOI: 10.1016/j.bmcl.2017.11.025

Experimental method

X-RAY DIFFRACTION (1.391 Å)