6ALB

CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)

6ALB の概要

• エントリーDOI: 10.2210/pdb6alb/pdb
• 関連するPDBエントリー: 6ALC
• 分子名称: CREB-binding protein, ZINC ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• 機能のキーワード: crebbp, bromodomain, small molecule inhibitor, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28459.51

構造登録者

Murray, J.M. (登録日: 2017-08-07, 公開日: 2018-10-17, 最終更新日: 2023-10-04)

• 主引用文献: Murray, J.M.; Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300; To be published,

実験手法

X-RAY DIFFRACTION (2.053 Å)