6ACR
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638
Summary for 6ACR
Entry DOI | 10.2210/pdb6acr/pdb |
Descriptor | Activin receptor type-1, N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, kinase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70328.37 |
Authors | Sakai, N.,Mishima-Tsumagari, C.,Matsumoto, T.,Shirouzu, M. (deposition date: 2018-07-27, release date: 2019-03-20, Last modification date: 2023-11-22) |
Primary citation | Sekimata, K.,Sato, T.,Sakai, N.,Watanabe, H.,Mishima-Tsumagari, C.,Taguri, T.,Matsumoto, T.,Fujii, Y.,Handa, N.,Honma, T.,Tanaka, A.,Shirouzu, M.,Yokoyama, S.,Miyazono, K.,Hashizume, Y.,Koyama, H. Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H). Chem. Pharm. Bull., 67:224-235, 2019 Cited by PubMed: 30828000DOI: 10.1248/cpb.c18-00598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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