6A84

Tankyrase-2 in complex with compound 15d

Summary for 6A84

• Entry DOI: 10.2210/pdb6a84/pdb
• Descriptor: Tankyrase-2, ZINC ION, 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one, ... (7 entities in total)
• Functional Keywords: tankyrase, parp, adp-ribosylation, transferase-transferase inhibitor complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 25138.01

Authors

Niwa, H.,Shirai, F.,Sato, S.,Yoshimoto, N.,Tsumura, T.,Okue, M.,Shirouzu, M.,Seimiya, H.,Umehara, T. (deposition date: 2018-07-06, release date: 2019-04-03, Last modification date: 2023-11-22)

• Primary citation: Shirai, F.,Tsumura, T.,Yashiroda, Y.,Yuki, H.,Niwa, H.,Sato, S.,Chikada, T.,Koda, Y.,Washizuka, K.,Yoshimoto, N.,Abe, M.,Onuki, T.,Mazaki, Y.,Hirama, C.,Fukami, T.,Watanabe, H.,Honma, T.,Umehara, T.,Shirouzu, M.,Okue, M.,Kano, Y.,Watanabe, T.,Kitamura, K.,Shitara, E.,Muramatsu, Y.,Yoshida, H.,Mizutani, A.,Seimiya, H.,Yoshida, M.,Koyama, H.; Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.; J. Med. Chem., 62:3407-3427, 2019; PubMed: 30883102; DOI: 10.1021/acs.jmedchem.8b01888

Experimental method

X-RAY DIFFRACTION (1.98 Å)