6ZOC
Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer
Summary for 6ZOC
Entry DOI | 10.2210/pdb6zoc/pdb |
Descriptor | Multidrug efflux pump subunit AcrB, HEXANE, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ... (16 entities in total) |
Functional Keywords | multidrug efflux pump, membrane protein, transport protein |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 5 |
Total formula weight | 388642.25 |
Authors | Tam, H.K.,Foong, W.E.,Pos, K.M. (deposition date: 2020-07-07, release date: 2021-05-19, Last modification date: 2024-01-31) |
Primary citation | Tam, H.K.,Foong, W.E.,Oswald, C.,Herrmann, A.,Zeng, H.,Pos, K.M. Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12:3889-3889, 2021 Cited by PubMed: 34188038DOI: 10.1038/s41467-021-24151-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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