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6ZFN

Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose

This is a non-PDB format compatible entry.
Summary for 6ZFN
Entry DOI10.2210/pdb6zfn/pdb
DescriptorGlycoprotein endo-alpha-1,2-mannosidase, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, SULFATE ION, ... (4 entities in total)
Functional Keywordsgolgi, hydrolase, mannosidase, retaining
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight45234.49
Authors
Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. (deposition date: 2020-06-17, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citationSobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J.
Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 117:29595-29601, 2020
Cited by
PubMed: 33154157
DOI: 10.1073/pnas.2013620117
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.1 Å)
Structure validation

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