6ZBV
Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7
Summary for 6ZBV
Entry DOI | 10.2210/pdb6zbv/pdb |
Related | 6ZPL |
Descriptor | Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone (3 entities in total) |
Functional Keywords | secondary active transport, neurotransmitter-sodium symport, amino acid transport, slc6a9, inward open state, inhibitor bound complex, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 78672.67 |
Authors | Shahsavar, A.,Stohler, P.,Bourenkov, G.,Zimmermann, I.,Siegrist, M.,Guba, W.,Pinard, E.,Sinning, S.,Seeger, M.A.,Schneider, T.R.,Dawson, R.J.P.,Nissen, P. (deposition date: 2020-06-09, release date: 2021-03-17, Last modification date: 2024-01-24) |
Primary citation | Shahsavar, A.,Stohler, P.,Bourenkov, G.,Zimmermann, I.,Siegrist, M.,Guba, W.,Pinard, E.,Sinning, S.,Seeger, M.A.,Schneider, T.R.,Dawson, R.J.P.,Nissen, P. Structural insights into the inhibition of glycine reuptake. Nature, 591:677-681, 2021 Cited by PubMed: 33658720DOI: 10.1038/s41586-021-03274-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
Download full validation report