6YV3
Structure of recombinant human beta-glucocerebrosidase in complex with galacto-configured cyclophellitol aziridine inhibitor
This is a non-PDB format compatible entry.
Summary for 6YV3
Entry DOI | 10.2210/pdb6yv3/pdb |
Related | 6YTP 6YTR 6YUT |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | beta-glucocerebrosidase, lysosomal glycoside hydrolase, gh30, hydrolase, cyclophellitol aziridine, inhibitor, complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 115729.28 |
Authors | Rowland, R.J.,Davies, G.J. (deposition date: 2020-04-27, release date: 2021-05-12, Last modification date: 2024-01-24) |
Primary citation | Rowland, R.J.,Chen, Y.,Breen, I.,Wu, L.,Offen, W.A.,Beenakker, T.J.,Su, Q.,van den Nieuwendijk, A.M.C.H.,Aerts, J.M.F.G.,Artola, M.,Overkleeft, H.S.,Davies, G.J. Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents. Chemistry, 27:16377-16388, 2021 Cited by PubMed: 34570911DOI: 10.1002/chem.202102359 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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