6YUH
Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site
Summary for 6YUH
Entry DOI | 10.2210/pdb6yuh/pdb |
Descriptor | Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, GLYCEROL, ... (6 entities in total) |
Functional Keywords | methyltransferase, complex, inhibitor, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 50099.14 |
Authors | Cederfelt, D.,Talibov, V.O.,Dobritzsch, D.,Danielson, U.H. (deposition date: 2020-04-27, release date: 2021-01-13, Last modification date: 2024-01-24) |
Primary citation | Talibov, V.O.,Fabini, E.,FitzGerald, E.A.,Tedesco, D.,Cederfeldt, D.,Talu, M.J.,Rachman, M.M.,Mihalic, F.,Manoni, E.,Naldi, M.,Sanese, P.,Forte, G.,Lepore Signorile, M.,Barril, X.,Simone, C.,Bartolini, M.,Dobritzsch, D.,Del Rio, A.,Danielson, U.H. Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22:1597-1608, 2021 Cited by PubMed: 33400854DOI: 10.1002/cbic.202000736 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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