6YOT

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with N,N-dimethylisoquinoline-5-sulfonamide and PKI (5-24)

Summary for 6YOT

• Entry DOI: 10.2210/pdb6yot/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N},~{N}-dimethylisoquinoline-5-sulfonamide, ... (4 entities in total)
• Functional Keywords: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43812.76

Authors

Oebbeke, M.,Heine, A.,Klebe, G. (deposition date: 2020-04-15, release date: 2021-04-28, Last modification date: 2024-01-24)

• Primary citation: Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G.; Fragment based drug design - Small chemical changes of fragments effecting big changes in binding; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.96 Å)