6YOT
Crystal structure of the cAMP-dependent protein kinase A cocrystallized with N,N-dimethylisoquinoline-5-sulfonamide and PKI (5-24)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41113.8 | 1 | UniProt (P25321) Pfam (PF00069) In PDB | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
2 | B | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P63248) In PDB | Mus musculus | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
3 | A | ~{N},~{N}-dimethylisoquinoline-5-sulfonamide | non-polymer | 236.3 | 2 | Chemie (P4W) | |||
4 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43340.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 472.6 | |
All* | Total formula weight | 43812.8 |