6YI1
Crystal structure of human glutaminyl cyclase in complex with Glu(gamma-hydrazide)-Phe-Ala
Summary for 6YI1
Entry DOI | 10.2210/pdb6yi1/pdb |
Descriptor | Glutaminyl-peptide cyclotransferase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glu(gamma-hydrazide)-Phe-Ala, ... (11 entities in total) |
Functional Keywords | alpha-beta protein, metalloprotein, transferase, intermediate |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 80302.53 |
Authors | Kupski, O.,Sautner, V.,Tittmann, K. (deposition date: 2020-03-31, release date: 2020-07-01, Last modification date: 2024-07-10) |
Primary citation | Kupski, O.,Funk, L.M.,Sautner, V.,Seifert, F.,Worbs, B.,Ramsbeck, D.,Meyer, F.,Diederichsen, U.,Buchholz, M.,Schilling, S.,Demuth, H.U.,Tittmann, K. Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease. Biochemistry, 59:2585-2591, 2020 Cited by PubMed: 32551535DOI: 10.1021/acs.biochem.0c00337 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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