6Y4M
Structure of Tubulin Tyrosine Ligase in Complex with Tb111
Summary for 6Y4M
Entry DOI | 10.2210/pdb6y4m/pdb |
Descriptor | Tubulin alpha-1B chain, (2~{R})-1-methylpiperidine-2-carboxylic acid, [(1~{R},3~{R})-1-acetyloxy-1-[4-methanoyl-5-(2-phenylmethoxyethyl)-2,3-dihydro-1,3-thiazol-2-yl]-4-methyl-pentan-3-yl]-methyl-azanium, ... (16 entities in total) |
Functional Keywords | ttl, tubulin, ligase, complex |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265376.99 |
Authors | Gavrilyuk, J.,Nocek, B.,Rigol, S.,Nicolaou, K.C.,Stoll, V. (deposition date: 2020-02-21, release date: 2021-03-31, Last modification date: 2024-06-19) |
Primary citation | Nicolaou, K.C.,Pan, S.,Pulukuri, K.K.,Ye, Q.,Rigol, S.,Erande, R.D.,Vourloumis, D.,Nocek, B.P.,Munneke, S.,Lyssikatos, J.,Valdiosera, A.,Gu, C.,Lin, B.,Sarvaiaya, H.,Trinidad, J.,Sandoval, J.,Lee, C.,Hammond, M.,Aujay, M.,Taylor, N.,Pysz, M.,Purcell, J.W.,Gavrilyuk, J. Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J.Org.Chem., 86:3377-3421, 2021 Cited by PubMed: 33544599DOI: 10.1021/acs.joc.0c02755 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.34 Å) |
Structure validation
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