6XVW
Catalytic domain of human PARP-1 in complex with the inhibitor MC2050
Summary for 6XVW
Entry DOI | 10.2210/pdb6xvw/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, NICKEL (II) ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, dna-repair, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 81030.58 |
Authors | Pfahler, J.,Steegborn, C. (deposition date: 2020-01-22, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Tomassi, S.,Pfahler, J.,Mautone, N.,Rovere, A.,Esposito, C.,Passeri, D.,Pellicciari, R.,Novellino, E.,Pannek, M.,Steegborn, C.,Paiardini, A.,Mai, A.,Rotili, D. From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. Acs Med.Chem.Lett., 11:862-868, 2020 Cited by PubMed: 32435397DOI: 10.1021/acsmedchemlett.9b00654 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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