6XSW
Structure of the Notch3 NRR in complex with an antibody Fab Fragment
Summary for 6XSW
Entry DOI | 10.2210/pdb6xsw/pdb |
Descriptor | Anti-N3 Fab Heavy Chain, Anti-N3 Fab Light Chain, Neurogenic locus notch homolog protein 3, ... (7 entities in total) |
Functional Keywords | notch3, antibody, signaling protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Rattus norvegicus More |
Total number of polymer chains | 12 |
Total formula weight | 318978.95 |
Authors | Bard, J. (deposition date: 2020-07-16, release date: 2021-07-21, Last modification date: 2023-10-25) |
Primary citation | Geles, K.G.,Gao, Y.,Giannakou, A.,Sridharan, L.,Yamin, T.T.,Zhang, J.,Karim, R.,Bard, J.,Piche-Nicholas, N.,Charati, M.,Maderna, A.,Lucas, J.,Golas, J.,Guffroy, M.,Pirie-Shepherd, S.,Roy, M.,Qian, J.,Franks, T.,Zhong, W.,O'Donnell, C.J.,Tchistiakova, L.,Gerber, H.P.,Sapra, P. NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2:100279-100279, 2021 Cited by PubMed: 34095881DOI: 10.1016/j.xcrm.2021.100279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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