6XKD
Structure of ligand-bound mouse cGAMP hydrolase ENPP1
Summary for 6XKD
Entry DOI | 10.2210/pdb6xkd/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 191818.79 |
Authors | Fernandez, D.,Li, L. (deposition date: 2020-06-26, release date: 2021-06-02, Last modification date: 2023-10-18) |
Primary citation | Carozza, J.A.,Brown, J.A.,Bohnert, V.,Fernandez, D.,AlSaif, Y.,Mardjuki, R.E.,Smith, M.,Li, L. Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP. Cell Chem Biol, 27:1347-1358.e5, 2020 Cited by PubMed: 32726585DOI: 10.1016/j.chembiol.2020.07.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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