Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6XKD

Structure of ligand-bound mouse cGAMP hydrolase ENPP1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001503biological_processossification
A0001570biological_processvasculogenesis
A0001649biological_processosteoblast differentiation
A0001822biological_processkidney development
A0001922biological_processB-1 B cell homeostasis
A0001958biological_processendochondral ossification
A0002009biological_processmorphogenesis of an epithelium
A0002021biological_processresponse to dietary excess
A0002269biological_processleukocyte activation involved in inflammatory response
A0002317biological_processplasma cell differentiation
A0002437biological_processinflammatory response to antigenic stimulus
A0003676molecular_functionnucleic acid binding
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0004528molecular_functionphosphodiesterase I activity
A0004551molecular_functiondinucleotide phosphatase activity
A0005044molecular_functionscavenger receptor activity
A0005509molecular_functioncalcium ion binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006096biological_processglycolytic process
A0006631biological_processfatty acid metabolic process
A0006955biological_processimmune response
A0007005biological_processmitochondrion organization
A0007224biological_processsmoothened signaling pathway
A0007507biological_processheart development
A0007605biological_processsensory perception of sound
A0007628biological_processadult walking behavior
A0008081molecular_functionphosphoric diester hydrolase activity
A0008270molecular_functionzinc ion binding
A0008283biological_processcell population proliferation
A0008340biological_processdetermination of adult lifespan
A0008344biological_processadult locomotory behavior
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009143biological_processnucleoside triphosphate catabolic process
A0009611biological_processresponse to wounding
A0009986cellular_componentcell surface
A0010035biological_processobsolete response to inorganic substance
A0010467biological_processgene expression
A0010945molecular_functioncoenzyme A diphosphatase activity
A0010960biological_processmagnesium ion homeostasis
A0014004biological_processmicroglia differentiation
A0015938biological_processcoenzyme A catabolic process
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016192biological_processvesicle-mediated transport
A0016323cellular_componentbasolateral plasma membrane
A0016462molecular_functionpyrophosphatase activity
A0016787molecular_functionhydrolase activity
A0016788molecular_functionhydrolase activity, acting on ester bonds
A0016791molecular_functionphosphatase activity
A0019634biological_processorganic phosphonate metabolic process
A0019725biological_processcellular homeostasis
A0021510biological_processspinal cord development
A0022010biological_processcentral nervous system myelination
A0030217biological_processT cell differentiation
A0030225biological_processmacrophage differentiation
A0030247molecular_functionpolysaccharide binding
A0030279biological_processnegative regulation of ossification
A0030282biological_processbone mineralization
A0030316biological_processosteoclast differentiation
A0030500biological_processregulation of bone mineralization
A0030502biological_processnegative regulation of bone mineralization
A0030505biological_processinorganic diphosphate transport
A0031103biological_processaxon regeneration
A0031214biological_processbiomineral tissue development
A0032026biological_processresponse to magnesium ion
A0032868biological_processresponse to insulin
A0033198biological_processresponse to ATP
A0034505biological_processtooth mineralization
A0034516biological_processresponse to vitamin B6
A0035128biological_processpost-embryonic forelimb morphogenesis
A0035264biological_processmulticellular organism growth
A0035630biological_processbone mineralization involved in bone maturation
A0035904biological_processaorta development
A0036076biological_processligamentous ossification
A0036119biological_processresponse to platelet-derived growth factor
A0036219molecular_functionGTP diphosphatase activity
A0036221molecular_functionUTP diphosphatase activity
A0038065biological_processcollagen-activated signaling pathway
A0042445biological_processhormone metabolic process
A0042474biological_processmiddle ear morphogenesis
A0042476biological_processodontogenesis
A0042593biological_processglucose homeostasis
A0042789biological_processmRNA transcription by RNA polymerase II
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042832biological_processdefense response to protozoan
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043588biological_processskin development
A0044297cellular_componentcell body
A0045444biological_processfat cell differentiation
A0045453biological_processbone resorption
A0045599biological_processnegative regulation of fat cell differentiation
A0046034biological_processATP metabolic process
A0046323biological_processglucose import
A0046716biological_processmuscle cell cellular homeostasis
A0046849biological_processbone remodeling
A0046872molecular_functionmetal ion binding
A0047429molecular_functionnucleoside triphosphate diphosphatase activity
A0047693molecular_functionATP diphosphatase activity
A0050951biological_processsensory perception of temperature stimulus
A0050954biological_processsensory perception of mechanical stimulus
A0051216biological_processcartilage development
A0051402biological_processneuron apoptotic process
A0051649biological_processestablishment of localization in cell
A0055062biological_processphosphate ion homeostasis
A0055074biological_processcalcium ion homeostasis
A0060291biological_processlong-term synaptic potentiation
A0060346biological_processbone trabecula formation
A0060348biological_processbone development
A0060350biological_processendochondral bone morphogenesis
A0060612biological_processadipose tissue development
A0060613biological_processfat pad development
A0060840biological_processartery development
A0061975biological_processarticular cartilage development
A0070254biological_processmucus secretion
A0070640biological_processvitamin D3 metabolic process
A0071344biological_processdiphosphate metabolic process
A0071529biological_processcementum mineralization
A0097241biological_processhematopoietic stem cell migration to bone marrow
A0097252biological_processoligodendrocyte apoptotic process
A0097440cellular_componentapical dendrite
A0097441cellular_componentbasal dendrite
A0098868biological_processbone growth
A0106177molecular_functioncyclic-GMP-AMP hydrolase activity
A0140459biological_processresponse to Gram-positive bacterium
A0140928biological_processinhibition of non-skeletal tissue mineralization
A1902742biological_processapoptotic process involved in development
A1904124biological_processmicroglial cell migration
A1904383biological_processresponse to sodium phosphate
A1904384biological_processcellular response to sodium phosphate
A1904738biological_processvascular associated smooth muscle cell migration
A1990787biological_processnegative regulation of hh target transcription factor activity
A1990874biological_processvascular associated smooth muscle cell proliferation
B0000902biological_processcell morphogenesis
B0001503biological_processossification
B0001570biological_processvasculogenesis
B0001649biological_processosteoblast differentiation
B0001822biological_processkidney development
B0001922biological_processB-1 B cell homeostasis
B0001958biological_processendochondral ossification
B0002009biological_processmorphogenesis of an epithelium
B0002021biological_processresponse to dietary excess
B0002269biological_processleukocyte activation involved in inflammatory response
B0002317biological_processplasma cell differentiation
B0002437biological_processinflammatory response to antigenic stimulus
B0003676molecular_functionnucleic acid binding
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0004528molecular_functionphosphodiesterase I activity
B0004551molecular_functiondinucleotide phosphatase activity
B0005044molecular_functionscavenger receptor activity
B0005509molecular_functioncalcium ion binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006096biological_processglycolytic process
B0006631biological_processfatty acid metabolic process
B0006955biological_processimmune response
B0007005biological_processmitochondrion organization
B0007224biological_processsmoothened signaling pathway
B0007507biological_processheart development
B0007605biological_processsensory perception of sound
B0007628biological_processadult walking behavior
B0008081molecular_functionphosphoric diester hydrolase activity
B0008270molecular_functionzinc ion binding
B0008283biological_processcell population proliferation
B0008340biological_processdetermination of adult lifespan
B0008344biological_processadult locomotory behavior
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009143biological_processnucleoside triphosphate catabolic process
B0009611biological_processresponse to wounding
B0009986cellular_componentcell surface
B0010035biological_processobsolete response to inorganic substance
B0010467biological_processgene expression
B0010945molecular_functioncoenzyme A diphosphatase activity
B0010960biological_processmagnesium ion homeostasis
B0014004biological_processmicroglia differentiation
B0015938biological_processcoenzyme A catabolic process
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016192biological_processvesicle-mediated transport
B0016323cellular_componentbasolateral plasma membrane
B0016462molecular_functionpyrophosphatase activity
B0016787molecular_functionhydrolase activity
B0016788molecular_functionhydrolase activity, acting on ester bonds
B0016791molecular_functionphosphatase activity
B0019634biological_processorganic phosphonate metabolic process
B0019725biological_processcellular homeostasis
B0021510biological_processspinal cord development
B0022010biological_processcentral nervous system myelination
B0030217biological_processT cell differentiation
B0030225biological_processmacrophage differentiation
B0030247molecular_functionpolysaccharide binding
B0030279biological_processnegative regulation of ossification
B0030282biological_processbone mineralization
B0030316biological_processosteoclast differentiation
B0030500biological_processregulation of bone mineralization
B0030502biological_processnegative regulation of bone mineralization
B0030505biological_processinorganic diphosphate transport
B0031103biological_processaxon regeneration
B0031214biological_processbiomineral tissue development
B0032026biological_processresponse to magnesium ion
B0032868biological_processresponse to insulin
B0033198biological_processresponse to ATP
B0034505biological_processtooth mineralization
B0034516biological_processresponse to vitamin B6
B0035128biological_processpost-embryonic forelimb morphogenesis
B0035264biological_processmulticellular organism growth
B0035630biological_processbone mineralization involved in bone maturation
B0035904biological_processaorta development
B0036076biological_processligamentous ossification
B0036119biological_processresponse to platelet-derived growth factor
B0036219molecular_functionGTP diphosphatase activity
B0036221molecular_functionUTP diphosphatase activity
B0038065biological_processcollagen-activated signaling pathway
B0042445biological_processhormone metabolic process
B0042474biological_processmiddle ear morphogenesis
B0042476biological_processodontogenesis
B0042593biological_processglucose homeostasis
B0042789biological_processmRNA transcription by RNA polymerase II
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042832biological_processdefense response to protozoan
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043588biological_processskin development
B0044297cellular_componentcell body
B0045444biological_processfat cell differentiation
B0045453biological_processbone resorption
B0045599biological_processnegative regulation of fat cell differentiation
B0046034biological_processATP metabolic process
B0046323biological_processglucose import
B0046716biological_processmuscle cell cellular homeostasis
B0046849biological_processbone remodeling
B0046872molecular_functionmetal ion binding
B0047429molecular_functionnucleoside triphosphate diphosphatase activity
B0047693molecular_functionATP diphosphatase activity
B0050951biological_processsensory perception of temperature stimulus
B0050954biological_processsensory perception of mechanical stimulus
B0051216biological_processcartilage development
B0051402biological_processneuron apoptotic process
B0051649biological_processestablishment of localization in cell
B0055062biological_processphosphate ion homeostasis
B0055074biological_processcalcium ion homeostasis
B0060291biological_processlong-term synaptic potentiation
B0060346biological_processbone trabecula formation
B0060348biological_processbone development
B0060350biological_processendochondral bone morphogenesis
B0060612biological_processadipose tissue development
B0060613biological_processfat pad development
B0060840biological_processartery development
B0061975biological_processarticular cartilage development
B0070254biological_processmucus secretion
B0070640biological_processvitamin D3 metabolic process
B0071344biological_processdiphosphate metabolic process
B0071529biological_processcementum mineralization
B0097241biological_processhematopoietic stem cell migration to bone marrow
B0097252biological_processoligodendrocyte apoptotic process
B0097440cellular_componentapical dendrite
B0097441cellular_componentbasal dendrite
B0098868biological_processbone growth
B0106177molecular_functioncyclic-GMP-AMP hydrolase activity
B0140459biological_processresponse to Gram-positive bacterium
B0140928biological_processinhibition of non-skeletal tissue mineralization
B1902742biological_processapoptotic process involved in development
B1904124biological_processmicroglial cell migration
B1904383biological_processresponse to sodium phosphate
B1904384biological_processcellular response to sodium phosphate
B1904738biological_processvascular associated smooth muscle cell migration
B1990787biological_processnegative regulation of hh target transcription factor activity
B1990874biological_processvascular associated smooth muscle cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvslgn.CClDFqetC
ChainResidueDetails
ACYS102-CYS122
ACYS146-CYS166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: AMP-threonine intermediate => ECO:0000269|PubMed:11027689
ChainResidueDetails
ATHR238
BTHR238

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369, ECO:0000269|PubMed:30356045
ChainResidueDetails
AASP200
BASP405
BHIS406
BHIS517
AASP358
AHIS362
AASP405
AHIS406
AHIS517
BASP200
BASP358
BHIS362

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369
ChainResidueDetails
ATHR238
BGLY785
BTYR787
BSER789
APHE781
ATYR783
AGLY785
ATYR787
ASER789
BTHR238
BPHE781
BTYR783

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:23027977, ECO:0007744|PDB:4GTY
ChainResidueDetails
AASN259
ALEU272
ALYS277
ATYR322
BASN259
BLEU272
BLYS277
BTYR322

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30356045
ChainResidueDetails
ASER514
BSER514

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6
ChainResidueDetails
ATHR896
BTHR896

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3
ChainResidueDetails
ATHR238
BTHR238

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN161
BASN161

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23027977
ChainResidueDetails
AASN267
BASN267

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369
ChainResidueDetails
AASN323
BASN323

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23041369
ChainResidueDetails
AASN459
BASN459

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23027977, ECO:0000269|PubMed:23041369
ChainResidueDetails
AASN567
BASN567

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23041369
ChainResidueDetails
AASN624
BASN624

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon