6XFP
Crystal Structure of BRAF kinase domain bound to Belvarafenib
Summary for 6XFP
Entry DOI | 10.2210/pdb6xfp/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | braf belvarafenib, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33524.27 |
Authors | Yin, J.,Sudhamsu, J. (deposition date: 2020-06-16, release date: 2021-03-10, Last modification date: 2023-10-18) |
Primary citation | Yen, I.,Shanahan, F.,Lee, J.,Hong, Y.S.,Shin, S.J.,Moore, A.R.,Sudhamsu, J.,Chang, M.T.,Bae, I.,Dela Cruz, D.,Hunsaker, T.,Klijn, C.,Liau, N.P.D.,Lin, E.,Martin, S.E.,Modrusan, Z.,Piskol, R.,Segal, E.,Venkatanarayan, A.,Ye, X.,Yin, J.,Zhang, L.,Kim, J.S.,Lim, H.S.,Kim, K.P.,Kim, Y.J.,Han, H.S.,Lee, S.J.,Kim, S.T.,Jung, M.,Hong, Y.H.,Noh, Y.S.,Choi, M.,Han, O.,Nowicka, M.,Srinivasan, S.,Yan, Y.,Kim, T.W.,Malek, S. ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. Nature, 594:418-423, 2021 Cited by PubMed: 33953400DOI: 10.1038/s41586-021-03515-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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