6XFP
Crystal Structure of BRAF kinase domain bound to Belvarafenib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 288 | 32832.6 | 1 | UniProt (H7C560) Pfam (PF07714) UniProt (by SIFTS) (P15056) | Homo sapiens (Human) | |
| 2 | B (A) | 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide | non-polymer | 478.9 | 1 | Chemie (V1Y) | |||
| 3 | C, D, E, F, G... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 4 | I (A) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 442 - 721 (UniProt: H7C560)
| PDB | External Database | Details |
|---|---|---|
| Met 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
| Ser 443 | Arg 443 | conflict |
| Lys 539 | His 539 | conflict |
| Ala 543 | Ile 543 | conflict |
| Ser 544 | Ile 544 | conflict |
| Lys 551 | Ile 551 | conflict |
| Arg 562 | Gln 562 | conflict |
| Asn 588 | Leu 588 | conflict |
| Ser 630 | Lys 630 | conflict |
| Glu 667 | Phe 667 | conflict |
| Ser 673 | Tyr 673 | conflict |
| Arg 688 | Ala 688 | conflict |
| Ser 706 | Leu 706 | conflict |
| Arg 709 | Gln 709 | conflict |
| Glu 713 | Ser 713 | conflict |
| Glu 716 | Leu 716 | conflict |
| Glu 720 | Ser 720 | conflict |
| Ser 722 | - | expression tag |
| Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32832.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 691.6 | |
| All* | Total formula weight | 33524.3 |
